using (SpreadsheetDocument spreadsheetDocument = SpreadsheetDocument.Open(filename, true))
{
WorkbookPart workBookPart = spreadsheetDocument.WorkbookPart;
WorkbookPart workbookPart = spreadsheetDocument.WorkbookPart;
WorksheetPart worksheetPart = workbookPart.WorksheetParts.First();
SheetData sheetData = worksheetPart.Worksheet.Elements<SheetData>().First();
//create a row
Row row1 = new Row() { RowIndex = 1U };
//create a new inline string cell
Cell cell = new Cell() { CellReference = "A1" };
cell.DataType = CellValues.InlineString;
//create a run for the bold text
Run run1 = new Run();
run1.Append(new Text("ABC"));
//create runproperties and append a "Bold" to them
RunProperties run1Properties = new RunProperties();
run1Properties.Append(new Bold());
//set the first runs RunProperties to the RunProperties containing the bold
run1.RunProperties = run1Properties;
//create a second run for the non-bod text
Run run2 = new Run();
run2.Append(new Text(Environment.NewLine + "XYZ") { Space = SpaceProcessingModeValues.Preserve });
//create a new inline string and append both runs
InlineString inlineString = new InlineString();
inlineString.Append(run1);
inlineString.Append(run2);
//append the inlineString to the cell.
cell.Append(inlineString);
//append the cell to the row
row1.Append(cell);
sheetData.Append(row1);
}